发明名称 |
SOLID SUPPORT AND METHOD FOR DETECTING AN ANALYTE IN A SAMPLE |
摘要 |
A solid support for detecting the presence of an analyte in a sample at or above a predetermined threshold comprises: a competitive analyte within said solid support, wherein said competitive analyte is coupled to a first member of a binding pair; a labelled conjugate within said solid support, downstream of said competitive analyte, wherein said analyte and said competitive analyte compete for binding to said conjugate; and a capture reagent immobilized within said solid support, downstream of said conjugate, wherein said capture reagent comprises a second member of the binding pair; wherein the affinity of the first and second members of the binding pair for one another and the distance between the conjugate and the capture reagent and/or the conjugate and the competitive analyte within the solid support are selected so as to increase the threshold of the solid support for the analyte. |
申请公布号 |
US2015080250(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201314395547 |
申请日期 |
2013.04.19 |
申请人 |
ZBX Corporation |
发明人 |
Shi Qinwei;Xu Jing |
分类号 |
G01N33/68;G01N33/548;G01N33/543 |
主分类号 |
G01N33/68 |
代理机构 |
|
代理人 |
|
主权项 |
1. A solid support for detecting the presence of an analyte in a sample at or above a predetermined threshold, the solid support comprising:
a competitive analyte within said solid support, wherein said competitive analyte is coupled to a first member of a binding pair; a labelled conjugate within said solid support, downstream of said competitive analyte, wherein said analyte and said competitive analyte compete for binding to said conjugate; and a capture reagent immobilized within said solid support, downstream of said conjugate, wherein said capture reagent comprises a second member of the binding pair; wherein the affinity of the first and second members of the binding pair for one another and the distance between the conjugate and the capture reagent and/or the conjugate and the competitive analyte within the solid support are selected so as to increase the threshold of the solid support for the analyte. |
地址 |
Toronto, Ontario CA |