| 摘要 |
The invention relates to selective oestrogen receptor modulators (SERMs) and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception. |
| 主权项 |
1. Compound of the general formula (I),in which
R1, R2, R3 and R4 independently of one another represent hydrogen, hydroxy, alkoxy, nitrile, alkylsulphonyl or represent the replacement of a CH group in the aromatic ring by a nitrogen atom or
provided one or more of the other substituents represent hydroxy, alkoxy, nitrile or alkylsulphonyl—independently of one another represent fluorine R5, R6 and R7 independently of one another represent hydrogen, fluorine, chlorine, bromine, methyl, ethyl, trifluoromethyl or nitrile, X represents hydrogen or alkyl-, cycloalkyl-, alkoxyalkyl, C3-C6-alkenyl or C3-C6-alkynyl which are optionally mono- or polysubstituted by halogen, hydroxy, —CN or deuterium, Y represents perfluorinated or partially fluorinated C1-C4-alkyl or perfluorinated or partially fluorinated C3-C8-cycloalkyl, m represents 4, 5, 6 or 7, n represents 2, 3, 4, 5, 6 or 7, p represents 0, 1 or 2 and q represents 1, 2, 3 or 4,and salts, solvates or solvates of the salts thereof, including all crystal modifications. |
