| 发明名称 |
SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE |
| 摘要 |
The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders. |
| 申请公布号 |
US2015080414(A1) |
申请公布日期 |
2015.03.19 |
| 申请号 |
US201414552122 |
申请日期 |
2014.11.24 |
| 申请人 |
BAYER INTELLECTUAL PROPERTY GmbH |
发明人 |
FOLLMANN Markus;STASCH Johannes-Peter;REDLICH Gorden;ACKERSTAFF Jens;GRIEBENOW Nils;KROH Walter;KNORR Andreas;BECKER Eva-Maria;WUNDER Frank;LI Volkhart Min-Jian;HARTMANN Elke;MITTENDORF Joachim;SCHLEMMER Karl-Heinz;JAUTELAT Rolf;BIERER Donald |
| 分类号 |
C07D471/04;A61K45/06;A61K31/506 |
主分类号 |
C07D471/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treatment of heart failure in humans and animals by administration of an effective amount of at least one compound of formula (I) in which R1 represents hydrogen or (C1-C4)-alkyl,
where (C1-C4)-alkyl may be substituted by one or two substituents independently of one another selected from the group consisting of fluorine and trifluoromethyl, or a salt thereof. |
| 地址 |
Monheim DE |
