COMPOUND HAVING CELL PROLIFERATION INHIBITORY ACTIVITY, PHARMACEUTICAL COMPOSITION AND SCREENING METHOD

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for therapy and/or prevention of a malignant tumor having a small influence on normal cells, tissues and organs, allowing proliferation inhibition or killing of only tumor cells, giving no adverse effect and being highly safe, by using a compound being resident in vivo and influencing a cellular signal transduction system.SOLUTION: A pharmaceutical composition for therapy and/or prevention of a malignant tumor comprises an effective amount of a compound represented by the formula 1 or a pharmaceutically acceptable salt thereof. X represents O or S, n represents 0, 1 or 2, m represents an integer of 0 to 5, l represents 0, 1 or 2, R and Rrepresent H, -CH, -CHOH, a hydroxymethyl group esterified with a phosphate group, or a hydroxymethyl group esterified with a phosphate group sharing a phosphate group of R and R, Rrepresents H, -CHor -CHOH, Rrepresents F, -NHor N, and W represents a heterocycle or a derivative thereof.