Anti-RANTES Antibodies

摘要

The invention relates to fully human monoclonal antibodies, and fragments thereof, that bind to the chemokine Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES, CCL5), thereby modulating the interaction between RANTES and one of more of its receptors, such as, e.g., CCR1, CCR3, CCR4 and CCR5, and/or modulating the biological activities of RANTES. The invention also relates to the use of these or any anti-RANTES antibodies in the prevention or treatment of immune-related disorders and in the amelioration of one or more symptoms associated with an immune-related disorder.

主权项

1. An isolated antagonist molecule of human RANTES, wherein said antagonist molecule binds a human RANTES polypeptide that comprises at least residues acid residues 16-18 of SEQ ID NO: 170 and reduces a biological activity of RANTES activity upon interaction between said antagonist and said human RANTES polypeptide.