发明名称 |
TARGETED HISTONE ACETYLATION |
摘要 |
The present disclosure provides compositions and methods for acetylating histones at targeted chromosomal locations in a cell. In particular, the disclosure provides a fusion protein comprising a DNA binding domain and at least one histone acetyltransferase (HAT) domain, such that the DNA binding domain targets the fusion protein to a targeted chromosomal location and the HAT domain acetylates histones at the targeted location. |
申请公布号 |
US2015079657(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201314381381 |
申请日期 |
2013.02.28 |
申请人 |
Ji Qingzhou;Kreader Carol |
发明人 |
Ji Qingzhou;Kreader Carol |
分类号 |
C12N9/10;C07K14/47 |
主分类号 |
C12N9/10 |
代理机构 |
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代理人 |
|
主权项 |
1. A fusion protein comprising a DNA binding domain and at least one p300 histone acetyltransferase (HAT) domain. |
地址 |
St. Louis MO US |