发明名称 |
METHODS OF MODULATING IMMUNE RESPONSES BY MODULATING TIM-1, TIM-2 AND TIM-4 FUNCTION |
摘要 |
The invention relates to methods of modulating immune responses in a subject such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them. |
申请公布号 |
US2015079085(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201414503768 |
申请日期 |
2014.10.01 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ;BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
Kuchroo Vijay K.;Chakravarti Sumone;Strom Terry;Zheng Xin Xiao;Meyers Jennifer |
分类号 |
C07K16/28;C07K14/705 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating or preventing a Th1-mediated disorder in a subject in need of such treatment, the method comprising administering to the subject a therapeutically effective amount of an agent that reduces expression or activity of tim-1, tim-2 or tim-4 in the subject. |
地址 |
Boston MA US |