发明名称 |
CELL-BASED ANTI-CANCER COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME |
摘要 |
Isolated pluralities of T cells which recognize at least one epitope of a mucosally restricted antigen and pharmaceutical compositions comprising the same are disclosed. Methods of making a plurality of T cells that recognize at least one epitope of a mucosally restricted antigen are also disclosed. Methods of treating an individual who has been diagnosed with cancer of a mucosal tissue or preventing such cancer in an individual at elevated risk are disclosed as are nucleic acid molecules that comprise a nucleotide sequence that encode proteins that recognize at least one epitope of a mucosally restricted antigen and T cells comprising such nucleic acid molecules. |
申请公布号 |
US2015079053(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201414548544 |
申请日期 |
2014.11.20 |
申请人 |
Thomas Jefferson University |
发明人 |
Waldman Scott A.;Snook Adam E. |
分类号 |
A61K35/14;C07K16/18;C07K14/705 |
主分类号 |
A61K35/14 |
代理机构 |
|
代理人 |
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主权项 |
1. An isolated plurality of T cells which recognize at least one epitope of a mucosally restricted antigen. |
地址 |
Philadelphia PA US |