POLYMERIC NANOCARRIERS WITH LINEAR DUAL RESPONSE MECHANISM

摘要

Nanocarriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to selectively deliver payloads within patients by responding to lower pH and/or ROS at localities within the patient. The present invention also features methods of synthesizing nanocarriers that are degraded by lower pH and/or ROS.

主权项

1. A nanocarrier comprising at least one polymer having a backbone that is stable at normal physiological pH and/or oxidative conditions, the backbone having a response element adapted to fragment the nanocarrier and a trigger moiety, wherein the trigger moiety activates in response to one of lower pH and reactive oxygen species (“ROS”) to trigger the response element.