Amorphous drug transdermal systems, manufacturing methods, and stabilization

摘要

The present invention refers to a transdermal delivery device comprising a) a non-crystallization inducing backing layer and a non-crystallization inducing release liner, both of which are substantially free of crystallization nuclei or crystallization seeding particles, b) an adhesive matrix layer comprising an adhesive matrix comprising an adhesive material and an active agent, wherein said active agent is dissolved or dispersed in a supersaturated concentration within said adhesive matrix, and wherein said active agent is in an amorphous form.