<p>The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.</p>
申请公布号
EP2646037(A4)
申请公布日期
2015.03.18
申请号
EP20110845528
申请日期
2011.11.29
申请人
THE AUSTRALIAN NATIONAL UNIVERSITY
发明人
STEPHENS, ROSS, WENTWORTH;PARISH, CHRISTOPHER, RICHARD;FREEMAN, CRAIG, GEOFFREY;SENDEN, TIMOTHY, JOHN