发明名称 |
COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME |
摘要 |
The present invention includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain embodiments, the invention comprises a compound comprising a protein degradation moiety covalently bound to a linker, wherein the ClogP of the compound is equal to or higher than 1.5. In other embodiments, the target protein contemplated within the invention comprises a posttranslational modified protein or intracellular protein. In yet other embodiments, compounds of the present invention are used to treat disease states wherein protein degradation is a viable therapeutic approach, such as cancer or any sort of oxidative stress disease state. |
申请公布号 |
EP2846784(A1) |
申请公布日期 |
2015.03.18 |
申请号 |
EP20130786919 |
申请日期 |
2013.05.10 |
申请人 |
YALE UNIVERSITY |
发明人 |
CREWS, CRAIG;GUSTAFSON, JEFF;ROTH, ANKE, GUNDULA;TAE, HYUN, SEOP;BUCKLEY, DENNIS;NEKLESA, TAAVI |
分类号 |
A61K31/045;A61K31/33;A61K38/16;A61P35/00 |
主分类号 |
A61K31/045 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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