发明名称 |
BICYCLIC SULFONE COMPOUNDS FOR INHIBITION OF RORy ACTIVITY AND THE TREATMENT OF DISEASE |
摘要 |
<p>The invention provides bicyclic sulfone compounds, pharmaceutical compositions, methods of inhibiting RORy activity, reducing the amount of iL-17 in a subject, and treating immune disorders and inflammatory disorders using such bicyclic sulfone compounds. Another aspect of the invention provides a method of treating a subject suffering from a medical disorder. The method comprises administering to the subject a therapeutically effective amount of one or more bicyclic sulfone compounds described herein. In certain other embodiments, the disorder is rheumatoid arthritis.</p> |
申请公布号 |
EP2846794(A1) |
申请公布日期 |
2015.03.18 |
申请号 |
EP20130787211 |
申请日期 |
2013.05.03 |
申请人 |
MERCK SHARP & DOHME CORP.;LYCERA CORPORATION |
发明人 |
AICHER, THOMAS;BARR, KENNETH;SIMOV, VLADIMIR;THOMAS, WILLIAM;TOOGOOD, PETER;VAN HUIS, CHAD |
分类号 |
A61K31/352;A61P29/00;A61P37/00;C07C311/40;C07D213/82;C07D215/38;C07D217/22;C07D223/16;C07D231/18;C07D233/72;C07D401/12 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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