| 摘要 |
<p>A method of mass spectrometry comprises automatically determining during an acquisition whether a first mass spectral data suffers from saturation or is approaching saturation. If this is true, the intensity of ions detected by a detector is automatically changed, for example by altering a transmission efficiency of a device or an ionisation efficiency of an ion source. A second mass spectral data is then obtained and one or more portions of the first mass spectral data is substituted with one or more corresponding portions of the second mass spectral data multiplied or scaled by an attenuation or scale factor and/or by another value. This forms a composite or combined mass spectrum comprising ion peaks from the first mass spectral data as well as the second mass spectral data. The invention provides an improved in-spectrum dynamic range and improves the duty cycle by only acquiring lower intensity data when saturation is present.</p> |
