| 发明名称 | Platelet aggregation inducing substance | ||
| 摘要 | A platelet aggregation inducing substance containing as an active ingredient a polypeptide having a peptide fragment represented by formula (1) (component A): -(Pro-X-Gly)n- (1) wherein X represents Pro or Hyp; and n represents an integer of from 20 to 5,000. | ||
| 申请公布号 | US8981059(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201414180355 | 申请日期 | 2014.02.14 |
| 申请人 | JNC Corporation | 发明人 | Umeda Yasuto;Takasaki Shinichi;Takebayashi Takafumi;Kawai Takahiro |
| 分类号 | A61K35/14;A61K38/17;C07K14/00;C07K14/78 | 主分类号 | A61K35/14 |
| 代理机构 | Jianq Chyun IP Office | 代理人 | Jianq Chyun IP Office |
| 主权项 | 1. A platelet aggregation inducing substance comprising as an active ingredient an un-crosslinked polypeptide having a peptide fragment represented by formula (1) (component A): -(Pro-X-Gly)n- (1) wherein n represents an integer of from 20 to 5,000, wherein the peptide fragment of formula (1) is selected from the group consisting of -(Pro-Pro-Gly)- (Component B) and -(Pro-Hyp-Gly)- (Component C), wherein the molar ratio of the Component B:Component C in said peptide fragment is 10/90 to 0/100, and wherein said un-crosslinked polypeptide is capable of inducing said platelet aggregation even in the presence of an inhibitory amount of aspirin, as compared to collagen. | ||
| 地址 | Tokyo JP | ||