MicroRNA patterns for the diagnosis, prognosis and treatment of melanoma

摘要

The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof.

主权项

1. A method for diagnosing melanoma in a subject, comprising obtaining from a tumor of a subject a sample comprising RNA and determining in said RNA the overexpression of a plurality of oncogenic miRs comprising miR-17 and at least one additional oncogenic miR, selected from the group set forth in Table 1, wherein the overexpression of the plurality of said oncogenic miRs is indicative of the subject having, or being susceptible to developing, metastatic melanoma.