Surface active agent compositions and methods for enhancing oxygenation, reducing bacteria and improving wound healing at a site of treatment

摘要

This present invention relates generally to the use of novel formulations comprising a surface active polymer to enhance oxygenation in skin and other soft tissue. The present invention also discloses formulations that can be used to improve clinical outlook and reducing bacteria. Methods of making and using the same are also disclosed.

主权项

1. A method for increasing oxygenation of a wound, comprising topically administering a composition selected from the group consisting of formulations A-U, wherein formulation A is: 17% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 75.0% poloxamer 188;
formulation B is: 15.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18%, disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 70.0% poloxamer 188; formulation C is: 13.67% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 65.0% poloxamer 188; formulation D is: 12% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 60.0% poloxamer 188; formulation E is: 10.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 55.0% poloxamer 188; formulation F is: 8.67% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 50.0% poloxamer 188; formulation G is: 7% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 45.0% poloxamer 188; formulation H is: 5.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.10% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 5.0% poloxamer 188; formulation I is: 5.33% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.20% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 5.0% poloxamer 188; formulation J is: 2.0% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 0.36% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.30% benzalkonium chloride, 0.06% fragrance, 0.17% iodopropynyl butylcarbamate, and 0.1% poloxamer 188; formulation K is: 2% aloe barbadensis leaf extract, 1.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.40% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 40.0% poloxamer 188; formulation L is: 3.67% aloe barbadensisl extract, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 0.50% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 35.0% poloxamer 188; formulation M is: 5.33% aloe barbadensis leaf extract, 12.33% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 1.0% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 30.0% poloxamer 188; formulation N is: 7.0% aloe barbadensis leaf extract, 15% linoleamidopropyl pg-dimonium chloride phosphate, 0.44% polysorbate 20, 0.44% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.18% disodium EDTA, 0.13% sodium benzoate, 2.0% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 25.0% poloxamer 188; formulation O is: 8.67% aloe barbadensis leaf extract, 1.0% linoleamidopropyl pg-dimonium chloride phosphate, 0.10% polysorbate 20, 1.0% sodium coco-pg dimonium chloride phosphate, 2.0% allantoin, 0.15% disodium EDTA, 0.10% sodium benzoate, 0.15% benzalkonium chloride, 0.15% iodopropynyl butylcarbamate, and 20% poloxamer 188; formulation P is: 10.33% aloe barbadensis leaf extract, 5% linoleamidopropyl pg-dimonium chloride phosphate, 1.0% polysorbate 20, 5.0% sodium coco-pg dimonium chloride phosphate, 4.0% allantoin, 0.80% disodium EDTA, 0.15% sodium benzoate, 0.50% benzalkonium chloride, 0.5% iodopropynyl butylcarbamate, and 15.0% poloxamer 188; formulation Q is: 12% aloe barbadensis leaf extract, 7.5% linoleamidopropyl pg-dimonium chloride phosphate, 4.0% polysorbate 20, 7.5% sodium coco-pg dimonium chloride phosphate, 8.0% allantoin, 1.5% disodium EDTA, 2.0% sodium benzoate, 0.75% benzalkonium chloride, 0.75% iodopropynyl butylcarbamate, and 10.0% poloxamer 188; formulation R is: 30% aloe barbadensis leaf extract, 20% linoleamidopropyl pg-dimonium chloride phosphate, 6.0% polysorbate 20, 10% sodium coco-pg dimonium chloride phosphate, 20% allantoin, 2.0% disodium EDTA, 3.13% sodium benzoate, 1.5% benzalkonium chloride, 1.5% iodopropynyl butylcarbamate, and 5.0% poloxamer 188; formulation S is: 15.33% aloe barbadensis leaf extract, 15% linoleamidopropyl pg-dimonium chloride phosphate, 8.0% polysorbate 20, 15% sodium coco-pg dimonium chloride phosphate, 15% allantoin, 3.0% disodium EDTA, 3.38% sodium benzoate, 1.5% benzalkonium chloride, 1.5% Iodopropynyl butylcarbamate, and 2.5% poloxamer 188: formulation T is: 17% aloe barbadensis leaf extract, 17.5% linoleamidopropyl pg-dimonium chloride phosphate, 9% polysorbate 20, 17.5% sodium coco-pg dimonium chloride phosphate, 18% allantoin, 4.5% disodium EDTA, 4% sodium benzoate, 1.75% benzalkonium chloride, 1.75% iodopropynyl butylcarbamate, and 1.0% poloxamer 188; formulation U is: 20% aloe barbadensis leaf extract, 10% linoleamidopropyl pg-dimonium chloride phosphate, 10% polysorbate 20, 20% sodium coco-pg dimonium chloride phosphate, 12% allantoin, 5.0% disodium EDTA, 5.0% sodium benzoate, 2.0% benzalkonium chloride, 2.0% iodopropynyl butylcarbamate, and 1.0% poloxamer 188, and wherein the composition further comprises about 10% to about 50% of a standard therapeutically effective amount of at least one therapeutic agent selected from the group consisting of antimicrobial agent, analgesics, and combinations thereof to the wound.