| 主权项 |
1. A polymeric prodrug comprising:
at least one polymer attached via at least one permanent bond to a bicine linker, the bicine linker being attached via a temporary linkage to an amine containing biologically active moiety; wherein the prodrug has the following structure:and
wherein:
T is D;D is a residue of an amine containing biologically active moiety;X is a spacer moiety;R2 and R3 are independently selected from the group consisting of hydrogen, acyl groups, and protecting groups for hydroxyl groups;R4 to R12 are independently selected from the group consisting of hydrogen, X—R1, substituted and non-substituted linear, branched and cyclical C1 to C8 alkyls and heteroalkyls, aryls, substituted aryls, substituted and nonsubstituted heteroaryls, cyano, nitro, halogen, carboxy, and carboxamide; andR1 is a polymer. |
