| 发明名称 |
Pharmaceutical formulations |
| 摘要 |
A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte. |
| 申请公布号 |
US8980256(B2) |
申请公布日期 |
2015.03.17 |
| 申请号 |
US201213678407 |
申请日期 |
2012.11.15 |
| 申请人 |
Amgen Inc. |
发明人 |
Li Tiansheng;Sloey Christopher James |
| 分类号 |
A61K39/00;C07K16/00;A61K9/19;A61K47/10;A61K9/00;A61K38/18;A61K38/19;A61K39/395;A61K47/02;A61K47/18;A61K47/26 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
Penn Michael G. |
| 主权项 |
1. A stable aqueous pharmaceutical formulation comprising an antibody at a concentration ranging from about 0.5 to about 3 mg/mL, benzyl alcohol at a concentration ranging from about 0.075 to about 0.105 M, and glycerol at a concentration ranging from about 5 to about 5.7 M. |
| 地址 |
Thousand Oaks CA US |
