Method and apparatus for producing a centred compression coated tablet

摘要

The present invention provides a method and apparatus for positioning the core of the compression coated tablet in manufacturing techniques for the production of such tablets.

主权项

1. A method of producing a compression coated tablet having a precisely centered pre-formed core such that more than 90% of the tablets produced have a deviation of the core position by less than 0.3 mm from the theoretical center, the method comprising the steps of:
(a) filling a die with a first powdered material; (b) contacting the powdered material in the die with a shaped punch assembly and applying pressure to the punch to create an imprint in the powdered material, the depth of the imprint being less than 1.5 mm, and the punch comprising a housing adapted to receive a pin which is movable within the housing, the pin having a protruding element at one end for engagement with a means for applying pressure to the pin and punch housing, said one end being opposite from the punching end, the pin being provided with a torsion means for engagement with the housing, in which the punch has a brake means for retarding movement of the pin in the housing; wherein the pin is held in a rest position by the torsion means to engage the protruding element of the pin with the means for applying pressure; (c) applying pressure to the protruding element of the pin to cause movement of the pin within the housing into the powdered material to create the imprint in the powdered material followed by return of the pin to its rest position; (d) depositing a pre-formed tablet core in the imprint created in the powdered material; (e) introducing a second powdered material into the die; and (f) contacting the second powdered material with the punch and applying pressure to the punch to form a fully coated compression coated tablet, such that the pin is held in its rest position in the housing by the brake means and the means for applying pressure is adapted so as to engage with the housing of the punch only and not to engage with the pin.