Therapeutic uses of allogeneic myeloid progenitor cells

摘要

Myeloid function is enhanced by transplantation or infusion of allogeneic myeloid progenitor cells, including CMP, GMP, MEP and MKP cell subsets. Myeloid progenitors ameliorate sequelae of anemia and thrombocytopenia, and can prevent or treat gastrointestinal mucositis associated with chemotherapy, radiotherapy, and the like. The transplantation or infusion may be performed in the absence of HLA typing, and the cells may be mismatched at one or more Class I HLA loci. The transplantation may provide for treatment of ongoing disease, or prevention of disease in high risk patients.

主权项

1. A method of providing myeloid function in a individual in need thereof, said method comprising:
transplanting into said individual a biologically effective dose of allogeneic myeloid progenitor cells.