Methods for making artificial ligaments and tendons

摘要

Prosthetic ligaments and tendons comprising ligament- or tendon-mimicking nanofibers and methods of making such nanofibers and prosthetic ligaments and tendons.

主权项

1. A method of making prosthetic ligament or tendon, comprising:
electrospinning a biocompatible polymer to form a plurality of ligament- or tendon-mimicking (LTM) nanofibers; and grouping the plurality of nanofibers into a multifilament having a secondary structure and exhibiting one or more properties selected from the group consisting of:
(a) a Young modulus of about 0.1-3000 MPa;(b) a tensile strength value of about 10-100 MPa;(c) a cross-sectional area of about 1-150 mm2;(d) a stiffness of about 50-1000 N/mm; and(e) an ultimate tensile load of about 1000-6000 N.