| 发明名称 | Compositions and methods for treating neoplasia, inflammatory disease and other disorders | ||
| 摘要 | The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail). | ||
| 申请公布号 | US8981083(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201113698010 | 申请日期 | 2011.05.16 |
| 申请人 | Dana Farber Cancer Institute, Inc. | 发明人 | Bradner James Elliott;Qi Jun |
| 分类号 | C07D243/10;A61K31/55;C07D495/12;C07D495/14;C07D519/00;C07D487/04;A61K31/5517 | 主分类号 | C07D243/10 |
| 代理机构 | Hamilton, Brook, Smith & Reynolds, P.C. | 代理人 | Hamilton, Brook, Smith & Reynolds, P.C. |
| 主权项 | 1. A compound represented by a structural formula selected from the group consisting of: or a pharmaceutically acceptable salt of any of the foregoing. | ||
| 地址 | Boston MA US | ||