| 发明名称 | Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA | ||
| 摘要 | The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Methionine Sulfoxide Reductase A (MSRA), in particular, by targeting natural antisense polynucleotides of Methionine Sulfoxide Reductase A (MSRA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of MSRA. | ||
| 申请公布号 | US8980858(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201113699356 | 申请日期 | 2011.05.25 |
| 申请人 | CuRNA, Inc. | 发明人 | Collard Joseph;Khorkova Sherman Olga |
| 分类号 | A61K48/00;C07H21/02;C07H21/04;A61K31/713;C12N9/02;C12N15/113 | 主分类号 | A61K48/00 |
| 代理机构 | CuRNA, Inc. | 代理人 | CuRNA, Inc. ;Browder Monte R. |
| 主权项 | 1. A method of upregulating a function of and/or the expression of a Methionine Sulfoxide Reductase A (MSRA) polynucleotide having SEQ ID NO: 1 in a mammal comprising: contacting said mammal with at least one antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide has at least 80% sequence identity to a reverse complement of a natural antisense of a Methionine Sulfoxide Reductase A (MSRA) polynucleotide; thereby upregulating a function of and/or the expression of the Methionine Sulfoxide Reductase A (MSRA) polynucleotide. | ||
| 地址 | Miami FL US | ||