发明名称 Tubulysine derivatives
摘要 The present invention relates to novel cytotoxic molecules and their use for the treatment of cancer and other diseases.
申请公布号 US8980833(B2) 申请公布日期 2015.03.17
申请号 US200812599663 申请日期 2008.05.09
申请人 R&D-Biopharmaceuticals GmbH 发明人 Richter Wolfgang
分类号 A61K38/05;C07K5/02;C07K5/078 主分类号 A61K38/05
代理机构 Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. 代理人 Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless Peter F.
主权项 1. A compound of Formula (IV), wherein R2 is C1-C4 alkyl; R6 is C1-C6 alkyl; R7 is C1-C6 alkyl, CH2-Phenyl, CH2OR19 or CH2OCOR20, wherein R19 is alkyl, R20 is phenyl, or CH2-Phenyl; R9 is C1-C6 alkyl; R10° is H, OH, O-alkyl or O-acetyl; f is 1 or 2; R11 is a group of the Formula (II) wherein R15 is a group of the formula wherein R21 is H, halogen, OH, NO2 NH2, CN, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxy, alkyl amino or dialkyl amino; R16 is H or CH3; R17 is CO2H, CO2R18, CONHNH2, OH, NH2, SH or an optionally substituted heteroalkyl or heterocycloalkyl group, wherein R18 is an optionally substituted alkyl, heteroalkyl or heterocycloalkyl group; and p is 0, 1, 2 or 3; or a pharmacologically acceptable salt, a solvate, a hydrate or a pharmacologically acceptable formulation thereof.
地址 Martinsried DE