| 主权项 |
1. A compound according to Formula (I):
X1-M-SEQ ID NO:2 (I)or a salt thereof, wherein:
SEQ ID NO:2 represents Xaa1-Xaa2-Xaa3-Glu-Val-Val-Ala-Leu-Ser-Xaa4-Xaa5, wherein:
Xaa1 is Tyr, Tyr(Me), Tyr(N-Me), Tyr(Me, N-Me), Tyr(I) or Tyr(I2);Xaa2 is Ser or a saccharide-modified serine;Xaa3 is Thr or a saccharide-modified threonine;Xaa4 is Arg or Arg(N-Me);Xaa5 is a non-natural amino acid selected from the group consisting of a D-isomer of a natural amino acid, arginosuccinic acid, citrulline, cysteine sulfinic acid, 3,4-dihydroxyphenylalanine, homocysteine, homoserine, ornithine, 3-monoiodotyrosine, 3,5-diiodotyrosine, 3,5,5′-triiodothyronine, 3,3′,5,5′-tetraiodothyronine, hydroxylysine, 4-hydroxyproline, an N-Cbz-protected amino acid, 2,4-diaminobutyric acid, homoarginine, N-methyl-arginine, norleucine, N-methylaminobutyric acid, naphthylalanine, phenylglycine, beta-phenylproline, tert-leucine, 4-aminocyclohexylalanine, N-methyl-norleucine, 3,4-dehydroproline, N,N-dimethylaminoglycine, N-methylaminoglycine, 4-aminopiperidine-4-carboxylic acid, Acp, AcpNH2, bAla, bAlaNH2, trans-4-(aminomethyl)-cyclohexanecarboxylic acid, 2-(aminomethyl)-benzoic acid, 3-(aminomethyl)-benzoic acid, 4-(aminomethyl)-benzoic acid, 1-aminocyclopentanecarboxylic acid, 1-aminocyclopropanecarboxylic acid, and 2-benzyl-5-aminopentanoic acid; and, X1-M is an optional group comprising a tagging element conjugated to the N-terminus of the amino acid sequence SEQ ID NO:2, wherein:
X1 is the tagging element, wherein the tagging element is selected from the group consisting of a transduction domain and a detection label; and, -M- is a single bond or an optional linking group forming a covalent linkage between the tagging element and the amino acid sequence SEQ ID NO:2. |
