Mixing device for liquid chromatography

摘要

A mixing device for liquid chromatography for the radial mixing of at least two fluids comprises a tubular mixing line, and a helical flow-guiding element arranged in the mixing line. One or more spacing elements located within an interior region of the mixing line are adapted to maintain a predetermined distance between the outer sides of the helical flow-guiding element and an inner wall of the mixing line. A mixing unit according to the present invention may include such a radial mixing device, with a longitudinal mixing device being connected downstream from this radial mixing device.

主权项

1. A mixing device for radially mixing at least two eluents in liquid chromatography, the mixing device comprising:
(a) a tubular mixing line having an inner surface defining an interior volume; (b) a helical flow-guiding wall located in the interior volume of the mixing line, the helical flow-guiding wall being helical about a longitudinal axis of the tubular mixing line and extending longitudinally along at least a portion of the length of the tubular mixing line, the helical flow-guiding wall also having an elongated shape in transverse section perpendicular to the longitudinal axis of the tubular mixing line so as to define two sub-volumes within the interior volume of the tubular mixing line; and (c) a number of spacing elements located within the interior volume of the mixing line and spaced apart along at least a portion of the length of the helical flow-guiding wall, each spacing element comprising a maximum radius portion of the helical flow-guiding wall and extending to the inner surface of the mixing line so as to maintain a predetermined distance between an outer edge of the helical flow-guiding wall and the inner surface of the mixing line in an adjacent region along the length of the helical flow-guiding wall in which adjacent region the helical flow-guiding wall has a radius less than the maximum radius portion.