| 摘要 |
<p>The invention provides a method of determining whether a pregnant subject has, or is predisposed to having, pregnancy-induced hypertension, gestational diabetes, or pre-eclampsia, the method comprising: a) measuring a level of sex hormone binding globulin (SHBG) in a biological sample obtained from a pregnant subject; b) measuring a level of placental growth factor (P1GF) in a biological sample obtained from the pregnant subject; c) comparing the SHBG level obtained from the pregnant subject with a reference SHBG level obtained from at least one subject having a normal pregnancy; and d) comparing the P1GF level obtained from the pregnant subject with a reference P1GF level obtained from at least one subject having a normal pregnancy, wherein the presence of levels of SHBG and P1GF present in the sample obtained from the pregnant subject below the reference levels indicates that the pregnant subject has, or is predisposed to having, pregnancy-induced hypertension, gestational diabetes, or pre-eclampsia. The invention also provides an array which may be used for detecting pregnancy-induced hypertension, gestational diabetes or pre-eclampsia and a method which may be used for determining whether a therapy is effective for treating these conditions.</p> |
