发明名称 |
Composition for cancer prognosis prediction comprising anti-TMAP/CKAP2 antibodies |
摘要 |
The present invention relates to an antibody which specifically binds to TMAP (tumor associated microtubule associated protein)/CKAP2 (cytoskeleton associated protein 2) or a fragment thereof, and a method for identifying the presence or absence of mitosis and a method for diagnosing cancer prognosis using the same. More specifically, the present invention relates to a composition for diagnosing cancer prognosis comprising an anti-TMAP/CKAP2 antibody or an antigen-binding site thereof, a method for detecting TMAP/CKAP2 using the composition, an anti-TMAP/CKAP2 antibody for diagnosing cancer prognosis, a method for providing information for diagnosing cancer prognosis using the composition, a method for screening a cancer therapeutic agent comprising the step of determining changes in the level of TMAP/CKAP2 antigen-antibody reaction by the treatment of a candidate substance, and a composition for determining cell-division cycles using the composition. |
申请公布号 |
US8980570(B2) |
申请公布日期 |
2015.03.17 |
申请号 |
US201113577126 |
申请日期 |
2011.02.01 |
申请人 |
National Cancer Center;Research and Business Foundation Sungyunkwan University |
发明人 |
Hong Kyeong Man;Bae Chang Dae;Park Joo Bae;Shin Chang Ho;Choi Yong Book |
分类号 |
G01N33/53;C07K16/30;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
Adler Benjamin Aaron |
主权项 |
1. A method for diagnosing breast cancer prognosis, comprising:
(a) treating a control sample separated from an individual known to have a good breast cancer prognosis and a sample separated from a test individual suspected of having breast cancer with an anti-TMAP/CKAP2 antibody or an antigen-binding fragment thereof; (b) comparing antigen-antibody reaction levels of step (a); and (c) determining the individual suspected of having breast cancer as a cancer patient having a poor prognosis when the antigen-antibody reaction level of the sample separated from the test individual is higher than that of the control sample in step (b); wherein the antibody comprises a heavy chain variable region comprising heavy chain CDR1 represented by SEQ ID NO. 38; heavy chain CDR2 represented by SEQ ID NO. 39; and heavy chain CDR3 represented by SEQ ID NO. 40 and a light chain variable region comprising light chain CDR1 represented by SEQ ID NO. 42; light chain CDR2 represented by SEQ ID NO. 43; and light chain CDR3 represented by SEQ ID NO. 44; or a heavy chain amino acid sequence represented by SEQ ID NO. 45 and a light chain amino acid sequence represented by SEQ ID NO. 46. |
地址 |
Goyang-si KR |