发明名称 |
Arginine inactivation of viruses |
摘要 |
The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is achieved in a neutral (pH ˜7) or near neutral (˜pH 6 to ˜pH 8) environment. |
申请公布号 |
US8980610(B2) |
申请公布日期 |
2015.03.17 |
申请号 |
US200913130540 |
申请日期 |
2009.11.20 |
申请人 |
Biogen Idec MA Inc. |
发明人 |
Selvitelli Keith;McCue Justin |
分类号 |
C12N7/06;C12N7/00;A61K39/21 |
主分类号 |
C12N7/06 |
代理机构 |
Sterne Kessler Goldstein & Fox P.L.L.C. |
代理人 |
Sterne Kessler Goldstein & Fox P.L.L.C. |
主权项 |
1. A method of inactivating or reducing the infectious titer of a retrovirus comprising contacting said virus with arginine, wherein said contacting occurs in a solution comprising at least about 0.2 M arginine and wherein said solution is at a pH above about 6.0. |
地址 |
Cambridge MA US |