Method of protecting biologically active substances against denaturation

摘要

A method of protecting a biologically active substance against denaturation, wherein a liquid (14) containing the active substance and a matrix-forming substance are deposited on a target surface (18) and dried so as to form a solid amorphous matrix (26) with the molecules of the active substance embedded therein, wherein an ink jet printer (10) is used for depositing the liquid (14) on the target surface (16) in the form of droplets (12) having a volume small enough to cause the liquid to dry when it impinges on the target surface (16) and to be held on the target surface through adhesion.

主权项

1. A method of protecting an active substance against denaturation, comprising the steps of:
depositing a liquid containing the active substance and a matrix-forming substance on a convex target surface of which at least a part of the target surface is formed by a surface of subcutaneous needles, by at least one ink jet printer in the form of droplets having a volume small enough to cause the liquid to dry when it impinges on the target surface and to be held on the target surface through adhesion, said step of depositing including the steps of:
moving at least one said ink jet printer across a regular array of the subcutaneous needles,controlling said at least one said ink jet printer to print onto the needles only, anddirecting nozzles of said at least one said ink jet printer onto tips of the needles with a jetting direction parallel with a direction of extension of the needles; and drying said deposited liquid so as to form a solid amorphous matrix with molecules of the active substance embedded therein.