| 发明名称 | Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents | ||
| 摘要 | The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. | ||
| 申请公布号 | US8980326(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201012873642 | 申请日期 | 2010.09.01 |
| 申请人 | Intezyne Technologies, Inc. | 发明人 | Sill Kevin N.;Skaff Habib;Breitenkamp Kurt |
| 分类号 | A61K9/14;C08J3/03;C08G65/26;C08G65/325;C08G65/333;C08G73/02;A61K9/107;A61K47/34 | 主分类号 | A61K9/14 |
| 代理机构 | Choate, Hall & Stewart LLP | 代理人 | Choate, Hall & Stewart LLP ;Reid Andrea L. C.;Nihan Danielle M. |
| 主权项 | 1. A multiblock copolymer of formula I: wherein: n is 275±10; m is 5-25; m′ is 5-50; Rx is a glutamic acid side-chain or an aspartic acid side-chain; Ry consists of a mixture of D- and L-amino acid side-chain groups selected from: D-benzylglutamate and L-benzylglutamate,D-benzylaspartate and L-benzylaspartate,D-leucine and L-tyrosine, orD-phenylalanine and L-tyrosine,wherein the Ry block is not in the form of an α-helix; R1 is —N3 or —OCH3; Q is a valence bond; and R2a is —NHC(O)CH3. | ||
| 地址 | Tampa FL US | ||