Compositions and methods for preventing cardiac arrhythmia

摘要

Disclosed herein are compositions and methods for treating or preventing cardiac arrhythmia in a subject.

主权项

1. A method of treating post-operative atrial fibrillation in a subject, comprising:
providing an extracellular matrix (ECM) composition comprising acellular ECM and a statin, said statin being linked to said ECM, wherein, when said ECM composition is administered to damaged cardiovascular tissue, said ECM composition modulates inflammation of said damaged cardiovascular tissue and induces myofibroblast proliferation and angiogenesis; and delivering a therapeutically effective amount of said ECM composition directly to post-operative damaged myocardium tissue of said subject, wherein, said ECM composition modulates inflammation of said damaged myocardium tissue and induces myofibroblast proliferation and angiogenesis and, thereby, bioremodeling and regeneration of new myocardium tissue, whereby said ECM composition modulates electrical activity of said subject's heart.