| 摘要 |
Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided. |
| 主权项 |
1. A biomaterial comprising:
at least one biopolymer comprising
naturally occurring amino groups andat least two bifunctional modifiers wherein each bifunctional modifier has the formula:
-A-[(CR1R2)m—O]n—ZA is a divalent moiety covalently bonded to the naturally occurring amino group of the biopolymer and Z is a monovalent moiety comprising a thiol group; at least one poly(alkylene oxide) cross-linked to at least two of the thiol groups of the biopolymer; wherein;
the divalent moiety is selected from the group consisting of —O—, —S—, C1-24-alkyl, C2-24-alkenyl, C2-24-alkynyl, C1-24-alkoxy, C1-24-heteroalkyl, C2-24-heteroalkenyl, C2-24-heteroalkynyl, cyano-C1-24-alkyl, C3-10-cycloalkyl, C3-10-cycloalkenyl, C3-10-cycloheteroalkyl, C3-10-cycloheteroalkenyl, acyl, acyl-C1-24-alkyl, acyl-C2-24-alkenyl, acyl-C2-24-alkynyl, carboxy, C1-24-alkylcarboxy, C2-24-alkenylcarboxy, C2-24-alkynylcarboxy, carboxy-C1-24-alkyl, carboxy-C2-24-alkenyl, carboxy-C2-24-alkynyl, aryl, aryl-C1-24-alkyl, aryl-C2-24-alkenyl, aryl-C2-24-alkynyl, heteroaryl, heteroaryl-C1-24-alkyl, heteroaryl-C2-24-alkenyl, heteroaryl-C2-24-alkynyl, sulfonate, arylsulfonate, and heteroarylsulfonate;at each occurrence R1 and R2 is independently selected from the group consisting of H, methyl, and ethyl;m is an integer from 2 to 8; andn is an integer ranging from 1 to 20,000. |
