| 发明名称 | PSA binding aptamer and method for diagnosis of prostate cancer | ||
| 摘要 | The present invention provides an aptamer that binds to prostate-specific antigen (PSA), the aptamer including: a preceding region having a random polynucleotide sequence consisting of from 1 to 10 nucleotides; a first region, at a 3′ end of the preceding region, consisting of nnnnCT wherein each n is independently selected from A, T, G and C; a second region consisting of nnCTTT wherein each n is independently selected from A, T, G and C, and at least one part of the second region is complementary to the first region; and a third region positioned between the first region and the second region and consisting of a random polynucleotide sequence having from 3 to 30 nucleotides. | ||
| 申请公布号 | US8981075(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201013806998 | 申请日期 | 2010.07.02 |
| 申请人 | National University Corporation Tokyo University of Agriculture and Technology | 发明人 | Ikebukuro Kazunori |
| 分类号 | C07H21/04;C12N15/115;G01N33/574 | 主分类号 | C07H21/04 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. An aptamer comprising: a preceding region having a random polynucleotide sequence consisting of from 1 to 10 nucleotides; a first region, at a 3′ end of the preceding region, consisting of nnnnCT wherein each n is independently selected from A, T, G and C; a second region consisting of nnCTTT wherein each n is independently selected from A, T, G and C, and at least one part of the second region is complementary to the first region; and a third region positioned between the first region and the second region and consisting of a random polynucleotide sequence having from 3 to 30 nucleotides, wherein the aptamer is capable of binding to prostate-specific antigen (PSA). | ||
| 地址 | Tokyo JP | ||