发明名称 |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof |
摘要 |
Novel activating receptors of the lg super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders. |
申请公布号 |
US8981061(B2) |
申请公布日期 |
2015.03.17 |
申请号 |
US201213690828 |
申请日期 |
2012.11.30 |
申请人 |
Novo Nordisk A/S |
发明人 |
Colonna Marco;Bouchon Axel;Salbo Rune;Wiberg Charlotte;Stennicke Vibeke W.;Henriksen Anette;Andersen Mette D. |
分类号 |
C07K16/00;C12P21/08;C07K16/28;C07K14/705 |
主分类号 |
C07K16/00 |
代理机构 |
|
代理人 |
Akopyan Nonna G.;Green Reza;Bork Richard W. |
主权项 |
1. An isolated antibody that specifically binds to a wild type human TREM-1 having a sequence as set forth in SEQ ID NO:3, wherein the antibody binds to an epitope comprising amino acid residues D38, K40, K75, Y90, H91 and R97. |
地址 |
Bagsvaerd DK |