Methods for manufacturing an antifungal agent

摘要

The present invention relates to an improved process for the preparation of Micafungin.

主权项

1. A one-pot process for the manufacturing of Micafungin or a salt thereof comprising the following order of steps:
a) mixing a compound of the formula (III)or a salt thereof, and a coupling additive selected from the group consisting of hydroxybenzotriazols and ethyl-2-cyano-2-(hydroxyimino)acetate in a solvent;
b) adding an coupling reagent to the mixture obtained in step a), wherein said coupling reagent is a carbodiimide; c) adding a base and a compound of formula (II)or a salt thereof to the mixture obtained in step b).