Polymerizable catonic peptide monomers and polymers

摘要

Disclosed herein are functionalized cationic peptide monomers: peptide chains of two or more positively charged amino acids chosen from lysine or arginine, or derivatives thereof, which are functionalized, meaning that they are bound to one or more polymerization moieties. The functionalized cationic peptide monomers can be described by the formula Z-Xaan-Z1n1 wherein Z and Z1 are polymerization moieties and n1 is an integer of 0 or 1; Xaa is each independently an amino acid Lys or Arg and n is an integer from 2 to 10 and wherein at least one Xaa amino acid of Xaa is Lys, wherein the carboxyl terminus of the amino acid sequence is amidated. Functionalized cationic peptide monomers can be combined and polymerized to form cell culture surfaces.

主权项

1. A prepolymer composition comprising at least two functionalized cationic peptide monomers of the formula:
Z-Xaan-Z1n1 wherein Z and Z1 are polymerization moieties, n1 is an integer of 0 or 1, each Xaa is independently an amino acid Lys or Arg, n is an integer of from 2 to 10, at least one Xaa is Lys, and the moiety Xaan is terminated by an amidated carboxyl group.