Polymerized cyclic nitroxide radical compound and use thereof

摘要

A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.

主权项

1. A polymerized nitroxide radical compound comprising a poly(ethylene glycol) chain segment in which the repeating unit of ethylene glycol is 15 to 10,000 and a polystyrene chain segment in which the repeating unit of styrene is 3 to 3,000, and at least 10% of the repeating units of styrene in the polystyrene chain segment at position 4 of the phenyl group, a residue of cyclic nitroxide radical compound being covalently bonded through a linking group selected from the group consisting of —CH2NH—, —CH2NHCH2—, —CH2O—, —CH2OCH2—, —CH2OCO— and —CH2OCOCH2—, and when present, the remainder of the position 4 being a halogen atom, a hydrogen atom or a hydroxyl group, and the cyclic nitroxide radical compound being selected from the group consisting of 2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl, 2,2,5,5-tetramethylpyrrolidine-1-oxyl-3-yl, 2,2,5,5-tetramethylpyrroline-1-oxyl-3-yl and 2,4,4-trimethyl-1,3-oxazolidine-3-oxyl-2-yl, 2,4,4-trimethyl-1,3-thiazolidine-3-oxyl-2-yl and 2,4,4-trimethyl-imidazolidine-3-oxyl-2-yl.