| 发明名称 | Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4 | ||
| 摘要 | The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of PAR4, in particular, by targeting natural antisense polynucleotides of PAR4. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PAR4. | ||
| 申请公布号 | US8980857(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201113697875 | 申请日期 | 2011.05.14 |
| 申请人 | CuRNA, Inc. | 发明人 | Collard Joseph;Khorkova Sherman Olga |
| 分类号 | C12N15/113;A61K31/7088 | 主分类号 | C12N15/113 |
| 代理机构 | CuRNA, Inc. | 代理人 | CuRNA, Inc. ;Browder Monte R. |
| 主权项 | 1. A method of upregulating a function of and/or the expression of a PAR4 polynucleotide in a biological system comprising: contacting said system with at least one antisense oligonucleotide 12 to 26 nucleotides in length wherein said at least one oligonucleotide is specific for and specifically hybridizes to a natural antisense polynucleotide of the PAR4 gene and has at least 80% sequence identity to a reverse complement of a natural antisense of a PAR4 polynucleotide; thereby upregulating a function of and/or the expression of the PAR4 polynucleotide wherein said natural antisense polynucleotide consists essentially of SEQ ID NO: 2. | ||
| 地址 | Miami FL US | ||