| 发明名称 | Inhibitors of β-secretase | ||
| 摘要 | The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. | ||
| 申请公布号 | US8981112(B2) | 申请公布日期 | 2015.03.17 |
| 申请号 | US201313784032 | 申请日期 | 2013.03.04 |
| 申请人 | Vitae Pharmaceuticals, Inc.;Boehringer-Ingelheim International GmbH | 发明人 | Bukhtiyarov Yuri;Cacatian Salvacion;Dillard Lawrence Wayne;Dorner-Ciossek Cornelia;Fuchs Klaus;Jia Lanqi;Lala Deepak S.;Morales-Ramos Angel;Reeves Jonathan;Singh Suresh B.;Venkatraman Shankar;Xu Zhenrong;Yuan Jing;Zhao Yi;Zheng Yajun;Rast Georg |
| 分类号 | C07D235/02;C07D403/06;C07D405/04;C07D405/06;C07C313/06;C07D407/06;C07C49/697;C07C255/47;C07C49/747;C07C331/14;C07C229/50;C07C49/755 | 主分类号 | C07D235/02 |
| 代理机构 | McCarter & English, LLP | 代理人 | McCarter & English, LLP ;Davis Steven G.;Zhang Xin |
| 主权项 | 1. A compound represented by a structural formula selected from:or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Fort Washington PA US | ||