发明名称 Tetrahydroisoquinolylsulphonamide derivatives, their preparation and their use in therapeutics
摘要 Compound corresponding to the formula I: in which: may adopt a value from 1 to 6 - (C) n-represents a -C1-6 alkylidene group, optionally substituted by 1 to 4 substituents; -R1 represents . a hydrogen atom , . a C1-6 alkyl group R2 represent . a hydrogen atom, . a C1-6 alkyl or C3-6 cycloalkyl group ,each of which is optionally substituted by 1 to 4 substituents; B represents . NR3R4, -where R3 and R4 represent, independently of one another, a C1-6 alkyl group or a hydrogen atom, or R3 and R4 together represent a C1-6 alkylidene, a group aC2-8 alkenylidene group, a C1-3 alkylidene-O-C1-3 alkylidene group or a C1-3 alkylidene-N (R5)-C1-3 alkylidene in which R5 represents a hydrogen atom, a C1-3 alkyle or C1-6 alkylcarbonyl group, it being possible for there C1-3 alkyle and C1-6 alkylcarbonyl group to be substituted, or . a cyclic amino,bonded via a carbon to the group-NR1-(C) n- such as aziridine, azetidine, pyrrolidine, piperidine or morpholine; The groups R3 and R4, and the cyclic amino being optionally substituted and the nitrogen atom being optionally substituted. Application in therapeutics
申请公布号 JO2877(B) 申请公布日期 2015.03.15
申请号 JO20050000071 申请日期 2005.05.23
申请人 SANOFI AVENTIS 发明人 DIAZ MARTIN JUAN ANTONIO;JIMENEZ BARGUENO MARIA DOLORES
分类号 A61K31/47;A61K31/472;A61K31/4725;A61K31/496;A61K31/5377;A61P3/04;A61P3/10;A61P25/00;C07D217/02;C07D217/04;C07D217/06;C07D401/12;C07D405/06;C07D409/06 主分类号 A61K31/47
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