| 发明名称 |
ANTIBODY WHICH SPECIFICALLY REACTS WITH HUMAN INTEGRIN A6B4 |
| 摘要 |
The purpose of the present invention is to provide an anti-ITGA6/B4 human antibody which is capable of inhibiting the adhesion of cancer cells in a bone marrow niche, and significantly increasing the strength of the effect of an anti-cancer drug against an anticancer-drug-resistant strain, by specifically recognizing the ITGA6B4 complex expressed on a cell membrane, and inhibiting the adhesion of the ITGA6B4 complex and laminin to one another. The present invention provides an antibody to integrin A6B4 which specifically recognizes the human integrin A6B4 complex and inhibits intercellular adhesion. |
| 申请公布号 |
WO2015034052(A1) |
申请公布日期 |
2015.03.12 |
| 申请号 |
WO2014JP73507 |
申请日期 |
2014.09.05 |
| 申请人 |
UNIVERSITY OF MIYAZAKI;FUJITA HEALTH UNIVERSITY;PERSEUS PROTEOMICS INC. |
发明人 |
MORISHITA KAZUHIRO;KANEDA KAZUKO;KUROSAWA YOSHIKAZU;KUROSAWA GENE;MITOMO KATSUYUKI;KOUDA KATSUSHI;UKAI YOSHINORI |
| 分类号 |
C12N15/09;A61K39/395;A61P1/00;A61P1/16;A61P1/18;A61P11/00;A61P13/08;A61P13/10;A61P15/00;A61P17/00;A61P35/00;A61P35/02;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08 |
主分类号 |
C12N15/09 |
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