A NOVEL PROCESS FOR THE PREPARATION OF TETRALIN AND NAPHTHALENE DERIVATIVES

摘要

The present invention relates to a novel process for the preparation of tetralin and naphthalene derivatives of formula (IV), including Agomelatine and pharmaceutical acceptable salts thereof. Such compounds are considered to be interesting either as useful building blocks or due to their biological activity. The compounds of formula (IV) are prepared from compounds of formula (I) via intermediates (III) by allylic rearrangement.