| 发明名称 |
Methods for Measuring Fat Digestibility and Uses Thereof |
| 摘要 |
The present invention provides methods for continuous measurement of triglyceride digestibility during a meal. A stable isotope labeled triglyceride and a free fatty acid tracer are added to the meal. The ratio between a ratio of isotope labeled fatty acid produced after digestion to free fatty acid tracer represents the percentage of digestion of triglycerides by lipase from the pancreas. |
| 申请公布号 |
US2015072366(A1) |
申请公布日期 |
2015.03.12 |
| 申请号 |
US201414543026 |
申请日期 |
2014.11.17 |
| 申请人 |
Deutz Nicolaas E.;Engelen Marielle P.;Com Guinur;Thaden John J. |
发明人 |
Deutz Nicolaas E.;Engelen Marielle P.;Com Guinur;Thaden John J. |
| 分类号 |
G01N33/92;C12Q1/61;C12Q1/44 |
主分类号 |
G01N33/92 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for determining reduced fat digestibility in an individual in need of such determination, comprising the step of:
administering a meal comprising a stable isotope labeled triglyceride and a free fatty acid tracer to said individual and a control subject; and measuring the amount of isotope labeled fatty acid formed after digestion of said isotope labeled triglyceride and measuring the amount of free fatty acid tracer in a biological sample of said individual and said control subject to determine a ratio of isotope labeled fatty acid to free fatty acid tracer for said individual and said control subject; wherein a lower ratio of labeled fatty acid to free fatty acid tracer in said individual compared to the ratio of labeled fatty acid to free fatty acid tracer from said control subject indicates that said individual has a reduced capacity to digest fat. |
| 地址 |
College Station TX US |
