| 发明名称 |
FLAP ENDONUCLEASE-1 AS A MARKER FOR CANCER |
| 摘要 |
Methods aiding in the assessment of cancer comprising use of the Flap endonuclease-1 protein (=FEN1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring FEN1 in the sample are disclosed. Measurement of FEN1 is useful for the early detection of cancer or in the monitoring of patients who undergo surgery for tumor removal. |
| 申请公布号 |
US2015072355(A1) |
申请公布日期 |
2015.03.12 |
| 申请号 |
US201414529702 |
申请日期 |
2014.10.31 |
| 申请人 |
Roche Diagnostics Operations, Inc. |
发明人 |
Wild Norbert;Hagmann Marie-Luise;Karl Johann;Riedlinger Julia;Roessler Markus;Tacke Michael |
| 分类号 |
G01N33/543;G06F19/00 |
主分类号 |
G01N33/543 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An in vitro method for assessing cancer in a patient, the method comprising:
(a) measuring a concentration of Flap endonuclease-1 protein and fragments thereof (FEN1), in a sample from the patient; (b) comparing the measured concentration of FEN1 to a reference concentration of FEN1; (c) assessing as being indicative of cancer where the measured concentration is increased when compared to the reference concentration. |
| 地址 |
Indianapolis IN US |
