METHODS AND COMPOSITIONS FOR REDUCING THE INCIDENCE OF POST-SURGICAL ADHESIONS

摘要

The disclosure relates to a method of reducing the incidence of post-surgical adhesions in a subject undergoing surgery. More specifically, the method relates to reducing the incidence of post-surgical adhesions with the topically administration of variants of activated protein C with cytoprotective and antiinflammatory activity to the internal organs and tissues exposed and/or manipulated during surgery. The disclosure is also related to reducing the incidence of post-surgical adhesions with the topically administration of a variant of activated protein C with cytoprotective activity and reduced or no anticoagulant activity.

主权项

1. A method of reducing the incidence of post-surgical adhesions in a subject undergoing surgery, the method comprising,
a) completing a primary surgery, b) topically administering an effective amount of a variant of activated protein C comprising cytoprotective activity, to the organs and tissues exposed by the primary surgery or subjected to surgical manipulation by the primary surgery, and c) closing a major incision associated with the primary surgery.