| 摘要 |
Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell. |
| 主权项 |
1. A functionalized fluorine containing phthalocyanine represented by Formula (I): wherein each Rf is independently selected from the group consisting of a fluorine atom, a fluorocarbon group containing from 1 to 18 carbon atoms, a fluorine containing group, a non-fluorine containing group, and combinations thereof, wherein at least one Rf includes a fluorine atom, wherein each R′ independently selected a fluorine containing group, a hydrogen atom, and combinations thereof, wherein M is one or more of a metal atom, a non-metal atom, a metal ion, a non-metal ion, at least one of a metal atom or non-metal atom coupled to at least one axial ligand, at least one of a metal or non-metal ion coupled to at least one axial ligand, and wherein R includes at least one of a reactive functional group or at least one cancer-targeting ligand (CTL). |
