发明名称 |
METHODS FOR GENETICALLY DIVERSIFIED STIMULUS-RESPONSE BASED GENE ASSOCIATION STUDIES |
摘要 |
Methods are provided for improving the impact of genetically diversified stimulus response gene association (GDSRGA) studies. The methods may involve developing subpopulations to be contrasted in GDSRGA studies by obtaining a biological sample from each donor of a population of donors; selecting a common cohort from the biological samples by obtaining at least a partial genomic sequence from each biological sample, aligning the sequences of the biological samples, and removing biological samples that cannot be sequenced accurately or fail to align; applying a test molecule or condition to the biological samples to induce phenotypically distinct responses among the members of the cohort; and segregating the biological samples into subpopulations based on the phenotypically distinct responses. These subpopulations may be used in GDSRGA studies. |
申请公布号 |
WO2015034878(A2) |
申请公布日期 |
2015.03.12 |
申请号 |
WO2014US53819 |
申请日期 |
2014.09.03 |
申请人 |
COYNE SCIENTIFIC , LLC |
发明人 |
COYNE, KEVIN P.;COYNE, SHAWN T. |
分类号 |
C12Q1/68;G06F19/18 |
主分类号 |
C12Q1/68 |
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