METHODS FOR PREPARING AZOXYSTROBIN AND INTERMEDIATE THEREOF

摘要

Disclosed is a method for preparing an intermediate of azoxystrobin represented by formula (1) and formula (2). The method comprises: in the presence of a catalyst, enabling a compound represented by formula (3) to be in contact with sodium methoxide and 4, 6-dichloropyrimidine to obtain a mixture of the intermediate represented formula (1) and formula (2), the catalyst being nitrogen heterobicycle compound or a salt thereof. Also disclosed is a method for preparing the azoxystrobin. The method comprises: enabling the intermediate represented by formula (2) and provided in the present invention to react with 2-cyanophenol or a salt thereof under the catalysis of the nitrogen heterobicycle compound or the salt thereof, so as to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has the outstanding advantages of high conversion rate, high product purity and simple operations and is environmentally friendly.